文献推荐：中美德研究人员首次用化学气相沉积法制备了一种新型的主链可降解的聚合物涂层，聚合物中插入活性基团，可通过点击化学反应进一步对材料进行修饰。进一步研究显示材料降解并未发现毒性反应，这项技术有望用于医疗器械表面涂层处理。
Backbone-Degradable Polymers Prepared by Chemical Vapor Deposition, Fan Xie1,2,†, Dr. Xiaopei Deng1,†, Dr. Domenic Kratzer3, Kenneth C. K. Cheng1, Dr. Christian Friedmann3, Dr. Shuhua Qi2, Dr. Luis Solorio1 andProf. Dr. Joerg Lahann1,3,*， Angewandte Chemie International Edition (2016). DOI: 10.1002/anie.201609307
Abstract
Polymers prepared by chemical vapor deposition (CVD) polymerization have found broad acceptance in research and industrial applications. However, their intrinsic lack of degradability has limited wider applicability in many areas, such as biomedical devices or regenerative medicine. Herein, we demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD. The CVD co-polymerization of [2.2]para-cyclophanes with cyclic ketene acetals, specifically 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy and ellipsometry. The degradation kinetics are dependent on the ratio of ketene acetals to [2.2]para-cyclophanes as well as the hydrophobicity of the films. These coatings address an unmet need in the biomedical polymer field, as they provide access to a wide range of reactive polymer coatings that combine interfacial multifunctionality with degradability.