Nature chemistry：RAFT活性聚合获重要进展

这项无传统有机硫链转移剂的RAFT活性乳液聚合成果将成为今年最漂亮的高分子化学合成研究。

【Gaofenzi.org高分子化学合成进展】RAFT聚合全称是可逆加成-断裂链转移聚合(Reversible Addition-Fragmentation Chain Transfer Polymerization),是活性/可控自由基聚合(CRP)的一种。截至目前，RAFT聚合研究N多年了（1998年左右起），但是由于活性聚合操作相对不易和RAFT聚合常常使用含硫的有机链转移剂，所以限制了其工业化生产及其用途。但是来自英国华威大学化学系（Warwick’s Department of Chemistry ）的研究人员近日在Nature chemistry发布报告介绍了一种快速可定量控制的有序多嵌段RAFT聚合反应，反应是在乳液中进行，反应中未使用任何传统的有机硫链转移剂或金属催化剂，所以制备的聚合物更加“绿色”，另外作者还成功进行了放大反应，研究人员称这项进展适合于工业化生产。据了解，这种适合商业生产的可控绿色活性聚合反应有望在纳米聚合物、医药和涂料等领域发挥重要作用。

小编一眼扫过上述结构式，每种至少包含20个嵌段吧。。。

更详细的内容请参考文献：Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization，Nikolaos G. Engelis, Athina Anastasaki, Gabit Nurumbetov, Nghia P. Truong, Vasiliki Nikolaou, Ataulla Shegiwal, Michael R. Whittaker, Thomas P. Davis & David M. Haddleton，Nature Chemistry(2016)doi:10.1038/nchem.2634

Translating the precise monomer sequence control achieved in nature over macromolecular structure (for example, DNA) to whole synthetic systems has been limited due to the lack of efficient synthetic methodologies. So far, chemists have only been able to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and iterative chemical strategies such as solid-state Merrifield-type approaches or molecularly dissolved solution-phase systems. Here, we report a rapid and quantitative synthesis of sequence-controlled multiblock polymers in discrete stable nanoscale compartments via an emulsion polymerization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer agent. This approach is environmentally friendly, fully translatable to industry and thus represents a significant advance in the development of complex macromolecule synthesis, where a high level of molecular precision or monomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as well as molecular information storage.

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